Pancreatic Cancer

Pancreatic Cancer: Symptoms, Causes & Treatment

Pancreatic cancer is a serious and often life-threatening condition that affects thousands of individuals worldwide. Despite being relatively rare, it has one of the lowest survival rates among major cancers, primarily due to its typically late diagnosis. This blog aims to shed light on pancreatic cancer, discussing its nature, types, symptoms, causes, and treatment options. Additionally, we’ll introduce some leading pancreatic cancer specialists and provide information on where to seek assistance, such as DocTrePat.

Introduction

Pancreatic cancer is a daunting diagnosis that brings with it a complex array of challenges. Located behind the stomach, the pancreas plays a critical role in digestion and blood sugar regulation. Cancer in this organ often progresses silently and is frequently diagnosed only in advanced stages, making treatment more difficult. Understanding the disease, its early signs, and treatment options is essential for improving outcomes and providing hope to those affected.

What is Pancreatic Cancer?

Pancreatic cancer arises when cells in the pancreas begin to grow uncontrollably, forming a malignant tumour. The pancreas, a glandular organ, is involved in producing enzymes that aid digestion and hormones like insulin that regulate blood sugar levels. There are two main functional components of the pancreas: the exocrine component, which produces digestive enzymes, and the endocrine component, which releases hormones into the bloodstream.

Types of Pancreatic Cancer

Pancreatic cancer is categorized based on the type of cell it originates from:

Pancreatic Adenocarcinoma: 

This is the most prevalent type, accounting for about 95% of cases. It starts in the exocrine cells that line the ducts of the pancreas.

Pancreatic Neuroendocrine Tumours (PNETs):

 These less common cancers originate in the endocrine cells. They can produce various hormones, leading to distinct symptoms depending on the hormone affected.

Acinar Cell Carcinoma:

A rare form of pancreatic cancer that begins in the acinar cells responsible for producing digestive enzymes.

Intraductal Papillary Mucinous Neoplasms (IPMNs):

These begin as benign cysts but have the potential to become malignant over time.

Other Rare Types:

 These include pancreatic sarcomas and lymphomas, which are very uncommon.

Symptoms of Pancreatic Cancer

Symptoms of pancreatic cancer often do not appear until the disease is advanced. When symptoms do present, they can be quite varied and nonspecific, including:

  • Jaundice: Yellowing of the skin and eyes due to bile duct obstruction.
  • Abdominal Pain: Pain or discomfort in the upper abdomen that may radiate to the back.
  • Weight Loss: Unintentional weight loss and loss of appetite.
  • Nausea and Vomiting: Often due to the cancer pressing on the stomach.
  • New-Onset Diabetes: Sudden development of diabetes, particularly in older adults.
  • Fatigue: Persistent, unexplained tiredness.
  • Changes in Stool: Light-coloured or greasy stools that float, indicating poor digestion of fats.

Causes of Pancreatic Cancer

The exact cause of pancreatic cancer is not well-understood, but several risk factors have been identified:

  1. Genetic Mutations:
    • BRCA1 and BRCA2 genes: Mutations in these genes are often linked to an increased risk of pancreatic cancer. These genetic mutations are also associated with a higher risk of other cancers, such as breast and ovarian cancer. Individuals with a family history of pancreatic cancer, especially those who have relatives with these genetic mutations, may have a greater risk.
    • Lynch syndrome: This genetic disorder increases the risk of various cancers, including pancreatic cancer.
  2. Smoking:
    • Long-term tobacco use is a significant risk factor for pancreatic cancer. The harmful chemicals in tobacco can cause DNA damage and inflammation, which may lead to cancerous growths. The longer and more intense the exposure to tobacco smoke, the higher the risk.
  3. Chronic Pancreatitis:
    • Chronic inflammation of the pancreas can increase the risk of pancreatic cancer. Chronic pancreatitis, often caused by long-term alcohol abuse or other underlying conditions, may lead to cell damage and alterations that promote cancer development.
  4. Diabetes:
    • Both type 1 and type 2 diabetes have been associated with a higher risk of pancreatic cancer. The relationship between the two conditions isn’t entirely clear, but some studies suggest that inflammation associated with diabetes could contribute to the development of pancreatic cancer.
  5. Family History:
    • A family history of pancreatic cancer increases the likelihood of developing the disease. Genetic factors may play a role, and the presence of other family members with pancreatic cancer suggests a potential hereditary risk.
  6. Obesity:
    • Increased body weight can elevate the risk of pancreatic cancer. Obesity may contribute to inflammation and insulin resistance, factors that can promote cancer development.
  7. Age:
    • The risk of pancreatic cancer typically increases with age. Most cases occur in individuals over 60, and the majority are diagnosed in people over 70.
  8. Diet and Lifestyle:
    • Diets high in red meat, processed foods, and low in fruits and vegetables have been associated with an increased risk of pancreatic cancer. Lifestyle factors such as lack of physical activity and excessive alcohol consumption can also contribute to the risk.

These risk factors often interact with one another, making pancreatic cancer a complex disease with multifactorial causes. Understanding and addressing these factors can be vital in preventive measures and early diagnosis.

Treatment of Pancreatic Cancer

The treatment of pancreatic cancer requires a multidisciplinary approach tailored to the individual patient’s condition. Options include:

Surgery:

Complete surgical removal of the tumour, such as the Whipple procedure, offers the best chance for a cure, especially when diagnosed early.

Radiation Therapy:

This treatment involves using high-energy rays to shrink tumours and kill cancer cells. It’s often used in conjunction with surgery and chemotherapy.

Chemotherapy:

Medications that target cancer cells to inhibit their growth. It can be administered before surgery (neoadjuvant) to shrink tumours or after surgery (adjuvant) to eliminate residual cancer cells.

Targeted Therapy:

Drugs that specifically target cancer cell pathways to slow or halt cancer growth.

Immunotherapy:

This treatment aims to stimulate the body’s immune system to fight cancer cells.

Doctors Specializing in Pancreatic Cancer

Dr. Surender Kumar Dabas:

An oncologist with expertise in treating pancreatic cancer, focusing on comprehensive, individualized care.

Dr. Michael Stevens:

A renowned gastroenterologist specializing in pancreatic diseases and interventions.

Dr. Leslie Hill:

A surgical oncologist with a specialized focus on pancreatic cancer surgery, including complex resections.

Dr. Peter Montrose:

A radiologist with extensive experience in imaging techniques for diagnosing and monitoring pancreatic cancer.

Dr. Sophia Lai:

An endocrinologist with a deep understanding of the hormonal aspects of pancreatic cancer and related metabolic disorders.

Conclusion

Pancreatic cancer is a complex and challenging disease, but advancements in medical research and treatment options offer hope. Understanding the risk factors and symptoms can lead to early detection and improved treatment outcomes. 

A multidisciplinary team of healthcare professionals, including Oncologists, Gastroenterologists, Surgeons, and Radiologists, plays a vital role in providing comprehensive care for patients with pancreatic cancer. If you or a loved one are facing this diagnosis, consider reaching out to DocTrePat for guidance and support in navigating your treatment journey.

In conclusion, pancreatic cancer remains a formidable adversary, but with early detection and modern treatments, there is  hope for improved outcomes and a better quality of life for patients. If you need assistance or further information, don’t hesitate to seek help from the expert medical team at DocTrePat.

Share Post On: